R-Alpha Lipoic Acid 60 CAaps From Jarrow Formulas
Bioavailability and Operation Superior*.
- No wheat, no gluten, no soybeans, no milk, no eggs, no fish, no peanuts/tree nuts.
- Suitable for vegetarians.
The majority of the products contain R-alpha lipoic acid (R-ALA) and S-alpha lipoic acid (S-ALA) as racemic mix. In particular, the equal amount of R-and S-shapes is formed during the alpha lipoic acid phase, and these products thus contain 1:1 ratio of R-ALA and S-ALA. R-ALA, however, is the only lipoic acid that is synthesized endogenously in humans and other species. Human pharmacokinetic studies demonstrate that after oral supplementation of racemic preparations, peak concentrations of R-ALA were 40-50 per cent higher than S-ALA, indicating that R-ALA has improve absorption and bioavailability. R-ALA supplementation in animal studies has shown improved biological effects such as insulin-stimulated glucose transport, glucose metabolism and antioxidant status. Therefore, R-ALA may provide superior health benefits in comparison with racemic mixtures (R-ALA and S-ALA) or S-ALA alone.
- Alpha lipoic acid only naturally occurring.
- Heat and safe shelf.
- Large quality of bioavailability.
- Antioxidant Universal + Biotin*
R-ALA acts in many ways to improve the cellular state of antioxidants* For example, lipoic acid supplementation significantly increases glutathione biosynthesis, a good antioxidant that protects cells against reactive oxygen species. In vitro studies have shown that lipoic acid stimulates the expression of gamma-glutamyl-cysteine ligase, glutathione pathology limiting level enzymes, along with the cellular uptake of cysteine, which is an amino acid necessary for glutathione synthesis, resulting in a total increase of 30-70 percent intracellular glutathione.
Research have shown that DHLA plays a crucial role in recycling many antioxidants, including vitamins and other redox molecules. For example, DHLA is superior to glutathione in its ability to regenerate vitamin C from the oxidized state. DHLA can also directly or indirectly reactivate alpha tocopherols by converting vitamin C into its reduced form and reducing oxidized alpha-tocopherol. Moreover, DHLA reactivates oxidized glutathione and prevents peroxidation of lipids. Recycled antioxidants including vitamin C and glutathione will reuse additional antioxidants such as vitamin E and keep the “antioxidant network” functioning properly. In the end, DHLA interacts with vitamin E.
Energy production and glucose and lipid metabolism systems
One of the major functions of the R-ALA is to increase the energy production by means of improved mitochondrial functions.* R-ALA is a disulfide and naturally is present in mitochondria as coenzyme for pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase Mitochondria also helps to protect against oxidative stress which can impair or delay mitochondria as an effective antioxidant.
Further, R-ALA is known to promote healthy glucose metabolism.
Supplementation supported blood glucose levels, insulin production and insulin susceptibility without recorded side effects in cline studies. This effective glucose metabolism also seems to lead to a balanced lipid metabolism.
The food and drug administration has not reviewed these claims. The drug is not intended for the diagnosis, care, treatment or prevention of disease.
R-alpha lipoic acid: Alpha lipoic acid in its natural form
The R-Alpha Lipoic Acid(R-ALA) and S-Alpha Lipoic Acid(S-ALA) racemic mixture are the majority of the ALA drugs. In general, equivalent quantities of R-and S-forms are produced in the alpha lipoic acid manufacturing process and therefore contain an equal ratio of R-ALA and S-ALA to 1:1. Nevertheless, R-ALA is the only lipoic acid which in humans and other organisms is endogenously synthesized.
Human pharmacokinetic studies have shown that after oral race preparation supplementation R-ALA concentrations of maximum are 40%-50% higher than S-ALA, indicating greater absorption and bioavailability of R-ALA. The R-ALA supplementation showed better biological effects in animal studies, such as glucose transport induced by insulin, glucose metabolism, and antioxide status. Thus R-ALA may provide superior health benefits in comparison to the racemic mixtures (R-ALA and S-ALA) or S-ALA alone.
Energy production and metabolism of glucose and lipid
R-ALA is a disulfide compound that is, of course, present in mitochondria as a coenzyme for pyruvate dehydrogenase, as well as alpha-keto-chlutarate dehydrogenase, and thus helps directly in the production of mitochondrial energy. Mitochondria is also a powerful antioxidant by protecting against mitochondrial pressure that may weaken or slow down mitochondria. * However, R-ALA is known to promote healthy glucose metabolism. * In clinical studies blood glucose levels, activity of insulin and insulin tolerance are supplemented without recorded adverse effects. This active glucose metabolism also tends to lead to better lipid metabolism*.
For example, lipoic acid addition significantly increases the biosynthesis of glutathione, a powerful antioxidant which protects cells from reactive oxygen species. In vitro studies have shown that lipoic acid stimulates the expression of gamma-glutamyl cysteine ligas, the rate of glutathione-based limiting enzyme, and the cellular uptake of cysteine, the amino acid needed for glutathione synthesis that generally increases intracellular glutathione by 30-70%.
Studies have demonstrated that DHLA plays a major role in the recovery of many nutrients, including vitamins and other redox systems. For example, the ability of DHLA to regenerate vitamin C from its oxidized state in comparison with glutathione was stated to be superior. DHLA can also directly or indirectly reactivate alpha-tocopherols by conversion of vitamin C to its reduced form and reduction of oxidized alpha-tocopherol. DHLA reactivates oxidized glutathione and prevents peroxidation of lipids. These recycled antioxidants, like vitamin C and glutathione, may further recover other antioxidants, such as vitamin E, to ensure a smooth operation of the “antioxidant network.” Finally, DHLA interacts with transportation systems dependent on NADPH or NADH for the recycling of vitamin E.
Step II detoxification enzymes inducer
R-ALA also stimulates the expression of different phase II enzyme detoxifier genes. Cells treated with lipoic acid, for instance, have shown a dose-and time based increase in the GSTA 2 gene expression, Glutathione S-transferase A2, a Phase 2 detoxification enzyme which leads to the removal of carcinogenes, drugs, environmental toxins and oxidative stress products.
Similarly, several studies have shown that lipoic acid supplementation induces neuroprotective Phase II detoxified enzymes, NAD(P)H: quinone oxidoreductase (NQO1) and glutathione-SA transferase (GST), both dose and time-dependent, in cultured neuroblastoma neurons (for example, human neuroblastoma SH-SY5Y and astrogolial cells, C6). Treatment may also increase endogenous antioxidants, resulting in additional neuroprotective effects. Thus, R-ALA supplementation may effectively eliminate toxins and unwanted materials and protect cells from various kinds of damage.
Biotin and its meaning supplementation
Biotin (B7) is an water-soluble vitamin B which coefficients most enzymes such as pyruvate, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and 3-methyl-CoA carboxylase. The enzymes play a critical role in gluconeogensis, synthesis of fatty acids, propionate metabolism, and leucine catabolism. Therefore, the addition of biotin along with R-ALA will further promote healthy metabolism and power generation.
If you are pregnant, lactating, trying to conceive, under 18 years old or taking medicine (especially for glucose management) (particularly for the treatment of diabetes), consult your health professional before using this drug.
About Jarrow Formulas
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