COENZYME Q10 : Explained by Machoah Vitamins & Supplements
COENZYME Q10 OTHER NAME(S):
Co Q10, Co Q-10, Coenzima Q-10, Co-Enzyme 10, Coenzyme Q 10, Coenzyme Q10, Co-Enzyme Q10, Co-Enzyme Q-10, Co-Q 10, CoQ10, Co-Q10, CoQ-10, Ubidecarenone, Ubidécarénone, Ubiquinone-10.
Coenzyme Q10 is a body-like vitamin substance, especially the substance of the heart, liver, kidney, and pancreatic. It is consumed in meat and seafood in small quantities. Coenzyme Q10 can also be produced in a laboratory.
Coenzyme Q10 is most commonly used in cardiac conditions such as heart failure, chest pain, and high blood pressure. It is also used to prevent migraine headache, Parkinson’s disease, and many others.
Coenzyme Q10 was first identified in 1957. The “Q10” refers to the chemical composition of the substance.
How does it work?
Coenzyme Q10 is an important vitamin-like substance necessary for the proper functioning of many organs and chemical reactions in the body. It helps to provide energy to cells. Coenzyme Q10 also appears to have antioxidant activity. People with certain diseases such as heart failure, high blood pressure, gum disease, Parkinson’s disease, or blood infections may have lower levels of coenzyme Q10.
Uses & Effectiveness
Probably effective for
Coenzyme Qu10 deficiency. Taking coenzyme Q10 by mouth seems to improve the symptoms of coenzyme deficiency Q10. The symptoms of this condition include weakness, fatigue and seizures.
Disorders restricting energy production in body cells (mitochondrial disruptions), while mouth-to-mouth coenzyme Q10 appears to reduce symptoms of mitochondrial disorders, but symptom improvement is slow.
Possibly Effective for
Age-related vision loss (age-related macular degeneration). A specific product that contains coenzyme Q-10, acetyl-L-carnitine and mouth omega-3 fatty acids (Phototrop) seems to improve visibility in people with vision loss associated with age.
Preventing death from heart disease. Taking coenzyme Q10 together with selenium could reduce the risk of cardiac death in the elderly. This research was carried out in Sweden. It is not known whether people living in other countries could receive the same benefit.
Heart failure. Early research has shown that heart failure can be associated with low coenzyme Q10 levels. Some research has shown that taking coenzyme Q10 may contribute to reducing some symptoms of heart failure.
Coenzyme Q10 may also reduce the likelihood of hospitalization with an abnormal heart rhythm, death, or heart failure.
Diabetes-related nerve damage (diabetic neuropathy). Research has shown that taking Q-10 coenzyme improves nerve damage and nerve pain in diabetics.
Fibromyalgia. Research shows that taking coenzyme Q10 by mouth seems to reduce the pain by more than 50 %, 47 %, morning fatigue by 56 %, and 44 %, in people with fibromyalgia.
AIDS / HIV. Taking coenzyme Q10 by mouth in people living with HIV / AIDS seems to improve immune function.
Blood vessel complications caused by heart bypass surgery. Reduced blood supplies can deprive tissue of oxygen during cardiac or blood vessel operations. The tissue can be damaged when the blood supply returns to the tissue.
Some evidence suggests that taking coenzyme Q10 by mouth at least one week prior to cardiovascular surgery or blood vessel surgery could help reduce tissue damage. However, this finding is not acceptable to all research.
A specific type of high blood pressure. In some people with high systolic blood pressure, but normal diastolic blood pressure (the bottom number), taking coenzyme Q10 by mouth daily seems lower systolic blood pressure (the top number).
Migraine headache. Taking coenzyme Q10 by mouth appears to help prevent headaches of migraines. Studies show that the frequency of headaches can be reduced by around 30% and the number of days with headache-related nausea by approximately 45% in adults. Over half of patients who take coenzyme Q10 experience a 50% decrease in the number of days of headache per month. Taking coenzyme Q10 also seems to reduce the frequency of migraine in children with low levels of coenzyme Q10. It can take up to 3 months to benefit substantially. It may take 3 months to see any benefit.
Multifunctional sclerosis (MS). Mouth coenzyme Q10 appears to reduce fatigue in people with MS, and low mood.
Muscle disorder is referred to as muscular dystrophy. Taking coenzyme Q10 orally appears in some people with muscle dystrophy to increase physical performance.
Heart attack. When started within 72 hours from a heart attack and taken for one year, the risk of cardiac events, including a further heart attack, would appear reduced by coenzyme Q10.
Painful erection in men (Disease of Peyronie). Research shows the erectile function of men with painful erections is improved when taking coenzyme Q10.
Possibly Ineffective for
Alzheimer’s disease. Coenzyme Q10 does not appear to improve their mental function in people with Alzheimer’s.
Neurodegenerative disease, or Lou Gehrig disease, called ALS disease. Research shows that coenzyme Q10 does not slow the progression of ALS.
Fatigue due to cancer drugs. In people treated for breast cancer, coenzyme Q10 does not appear to reduce tiredness.
Cocaine dependence. The use of cocaine is not reduced by a combination of Q10 and L-carnitine.
Symptoms affecting polio survivors (post-polio syndrome). Research shows that coenzyme Q10 does not improve muscle strength or muscle function in people with post-polio syndrome.
Probably ineffective for
Athletic performance. In athletes or non-athlatesby mouth, alone or with other ingredients, coenzyme Q10 is not improved.
An inherited neurological disorder called the disease of Huntington. The US has granted Ubiquinol, a form of coenzyme Q10, the’ Orphan Drug Status.’ Food and Drug Administration (FDA). This gives the maker of Ubiquinol some financial stimulus to study the effectiveness of Ubiquinol in the case of Huntington, a condition so rare (which affects less than 200,000 people) that pharmaceutical companies would otherwise not be able to invest in drug development. However, one major research study shows that taking large doses of coenzyme Q10 (2.4 grams a day) for up to 5 years does not hinder the signs of Huntington’s disease.
Insufficient Evidence for
Chest pain (angina). Some early research suggests that mouth coenzyme Q10 may reduce chest pain and improve your angina patient skills.
Heart toxicity caused by cancer drugs. Early research suggests that the use of coenzyme Q10 by mouth can protect the heart from being treated with drugs known as anthracyclines in children aged 3 to 12 years. However, the results of major studies are inconsistent.
Asthma. Some early research suggests that taking a combination of coenzyme Q10, vitamin E (alpha-tocophherol), and vitamin C, in addition to conventional asthma therapy, decreases the dose of medications needed by people with mild to moderate asthma. However, it does not seem to improve lung function or reduce airway blockage.
Autism. Early research reveals that taking some form of coenzyme Q10 called ubiquinol improves autism symptoms in autism patients aged 3-6 years, according to a parent assessment. Higher quality studies are required to confirm these results.
Mental health disorder of extreme mood swings (bipolar disorder). Early research shows that the symptoms of depression in people over 55 years of age with bipolar disorder are improved with coenzyme Q10.
The breast cancer. Some research in Chinese women shows that low blood concentrations of Q10 coenzyme are associated with increased risk of breast cancer. Early research has also shown that taking coenzyme Q10 orally in combination with operations and conventional treatment, along with other antioxidants, omega-3 and omega-6 fatty acids, may be helpful in advanced breast cancer. Higher quality studies are needed to confirm these results.
Cancer. Low levels of coenzyme Q10 appear to pose an increased risk of skin cancer. Early research suggests that coenzyme Q10 and other antioxidants increase their survival time by 40% in patients with terminal cancer. Higher quality studies are required to confirm these results.
Brain damage affecting muscle movement (brain ataxia). In early research, coenzyme Q10 can be taken by mouth to improve posture and muscle function in people with cerebellar ataxia and low Q10 concentration. However, it does not seem to be advantageous for people with normal coenzyme Q10 levels.
Chronic obstructive pulmonary disease (COPD) is a pulmonary disease. Early research shows that taking Q10 coenzyme in people with COPD does not improve lung function or exercise performance.
Cyclic vomiting syndrome. Early research suggests that coenzyme Q10 may work along with prescription drugs to treat
cyclic vomiting syndrome.
Diabetes. Research on the effectiveness of coenzyme Q10 for diabetes is unclear. Some research shows that coenzyme Q10 may slightly lower blood sugar levels in people with type 2 diabetes. However, there was no benefit from other research in people with type 1 or type 2 diabetes.
Weakened and enlarged heart (diluted cardiomyopathy). In early research, taking coenzyme Q10 improves children’s cardiomyopathic function.
Dry mouth. Early research suggests that dry mouth improves with an altered form of Q10 coenzyme based on ubicinol.
Eye surgery. Research has shown that the use of an eye solution containing coenzyme Q10 and vitamin E increases the speed of nerve regeneration after a cataract eye operation.
Rare inherited disease (ataxia from Friedreich) causing nerve damage. Early research has shown that coenzyme Q10
plus vitamin E improves heart function, but does not improve posture or walking in people with Friedreich ataxia.
However, other early studies indicate that taking vitamin E together with coenzyme Q10 helps to prevent coordination, posture, and movement in people with Friedreich ataxia compared to no treatment. Coenzyme Q10 appears to work best for baseline patients with low coenzyme Q10 levels.
Hearing loss. Some research suggests that specific mouth-consuming Q10 (Q-TER) coenzyme improves hearing in people with age-related hearing loss. However, in people with sudden surdity, combining coenzyme Q10 with conventional steroid therapy does not improve hearing more than steroid treatment alone. It also does not seem to improve hearing in people with noise-induced hearing loss.
Hepatitis C. Research shows that the use of Q-10 does not increase the function of hepatitis C in people who do not respond to conventional treatment.
High blood pressure. Some research has found that taking coenzyme Q10 alone or with other high-pressure medicines helps to reduce blood pressure in people with high blood pressure. But not all research has proved beneficial.
Coenzyme Q10 can only benefit people with high blood pressure who also have diabetes or low blood levels of coenzyme Q10 before therapy.
A condition of an enlarged heart called hypertrophic cardiomyopathy. Taking coenzymeQ-10 by mouth appears to reduce heart thickness and breathlessness and fatigue symptoms in people with hypertrophic cardiomyopathy.
Male infertility. Early evidence has shown that taking coenzyme Q10 or an altered form of coenzyme Q10 called ubiquinol by mouth may increase sperm movement and density in men with certain types of infertility. These benefits appear to require at least 6 months of treatment. However, these improvements may not increase the rate of pregnancy.
Inherited diabetes and deafness. Early research has shown that the use of coenzyme Q10 by mouth could prevent the development of a rare, maternally inherited form of diabetes.
Parkinson’s disease. Some research shows that coenzyme Q10 use alone or in conjunction with other supplements can mentally decrease in people with Parkinson’s early-stage disease. For these benefits, it seems necessary to have at least 16 months of treatment and doses above 600 mg a day. However, not all data were positive. Some research has shown that coenzyme Q10 does not benefit individuals with early or mid-stage disease of Parkinson.
Procedure to improve heart blood flow (percutaneous coronary procedure or PCI). Early research shows that taking 1 dose of Q10 2 hours of coenzyme before PCI does not reduce the risk of heart muscle injury. It also does not seem to prevent serious heart-related events during the month following the procedure.
Gum disease. Coenzyme Q10 is not effective in the treatment of gum disease. Early evidence, however, shows that coenzyme Q10 mouth treatment may be helpful.
Rare genetic disorder called the syndrome of Prader-Willi. Early research suggests that using coenzyme Q10 in children with Prader-Labhart-Willi syndrome improves mental and physical development. However, it is not clear whether these improvements are due to coenzyme Q10 or an age-related phenomenon.
High cholesterol. Whether coenzyme Q10 decreases cholesterol is not clear. One study shows that triglycerides are 20% lower and a small amount of LDL (or “bad” cholesterol). Other studies showed no benefit from taking coenzyme Q10 to lower overall cholesterol or LDL levels or to increase HDL (or “good” cholesterol). It can take at least three months to see any benefit.
High blood pressure during pregnancy (pre-eclampsia). Pre-eclampsia is a disease some women experience during pregnancy. Some research shows that women at risk have a lower risk of developing their condition if they take coenzyme Q10 from week 20 until their baby is born.
Prostate cancer. Research has shown that taking a combination of vitamin E, selenium, vitamin C, and coenzyme Q10 does not improve biomarkers of prostate cancer.
Kidney failure. In some early research, coenzyme Q10 improves the function of the kidneys in people with end-stage
renal disease. But other research shows that taking coenzyme Q10 does not improve the function of the kidney.
Blood infection called “sepsis”. Early research shows that taking a specific form of ubicinol-known coenzyme Q10 at the hospital for 7 days does not prevent death or reduce time due to blood disease.
A muscle condition called “statin inducing myopathy,” which Statins, a group of medicines used for lower
cholesterol, can sometimes cause muscle pain. It can be shown that taking Q10 coenzyme can reduce this pain. Not all the proof was positive, though.
Hair loss related to use of the warfarin. There is early evidence that the use of coenzyme Q10 may help prevent hair loss caused by warfarin.
Wrinkled skin. Early evidence suggests that applying coenzyme Q10 to the skin improves skin wrinkling.
More evidence is required to evaluate the use of coenzyme Q10.
Side Effects & Safety
Coenzyme Q10 is LIKELY safe when taken or applied directly to gums in most adults. Although coenzyme Q10 is well tolerated by most people, it can cause mild side effects, including stomach upset, loss of appetite, sickness, vomiting, and diarrhea. Some people may experience skin rashes that are allergic. It can also reduce blood pressure, so check your blood pressure carefully when your blood pressure is very low. By taking smaller amounts 2 or 3 times a day instead of large amounts at once, dividing the total daily dose can help to reduce side effects.
Coenzyme Q10 is safe for mouth-taking children. However, coenzyme Q-10 should not be used in children without medical supervision.
Special Warnings and Precautions:
Pregnancy and breast-feeding: Coenzyme Q10 is POSSIBLY safe if taken properly in the mouth during pregnancy.
Coenzyme Q10 was used safely from 20 weeks until delivery twice daily. The use of coenzyme Q10 in breast feeding is not well known. Keep on the safe side and avoid using it.
Chemotherapy: people who are chemotherapy with a drug class known as alkylating agents should be careful when using
coenzyme Q10. There are concerns that coenzyme Q10 may reduce the effectiveness of these medicines. Some alkylating agents include busulfan, carboplatin, cyclophoshamide, cytoxan, dacarbazine, thiotepa, etc. High blood pressure or
low blood pressure: coenzyme Q10 may decrease blood pressure. The effects of drugs used to lower blood pressure can be increased. Talk to your healthcare provider about your use of coenzyme Q10 if you have problems with blood pressure.
Smoking: smoking cigarettes reduces the amount of Q10 coenzyme stored in the body.
Surgery: Coenzyme Q10 may interfere with blood pressure control during and after surgery. Stop using coenzyme Q10 at least two weeks prior to planned operation.
Be careful about this combination
Medications for cancer (Chemotherapy) interacts with COENZYME Q10
The Q-10 is an anti-oxidant. Antioxidants may decrease the efficacy of some medicines used for cancer. There’s concern. It is, however, too early to know whether the interaction is taking place.
Medications for high blood pressure (Antihypertensive drugs) interacts with COENZYME Q10
Coenzyme Q-10 appears to decrease blood pressure. Using coenzyme Q10 and high blood pressure medicines may make your blood pressure too low.
>Captopril (Capoten), elapril (Vasotec), loartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many more
may be the cause of some high blood pressure medications.
Warfarin (Coumadin) interacts with COENZYME Q10
Warfarin (Coumadin) is used for slow blood coagulation. Coenzyme Q-10 may contribute to blood coagulation. By supporting the blood clot, coenzyme Q-10 can reduce the efficacy of warfarin (coumadin). Reducing the effectiveness of warfarin (Coumadin) may increase the risk of coagulation. Make sure that your blood is checked regularly. It may be necessary to change the dose of warfarin (Coumadin).
The following doses have been studied in scientific research:
For coenzyme Q10 deficiency: 150-2400 mg per day.
For conditions that limit body cell energy generation (mitochondrial disorders): 150-160 mg / day, or two mg / kg / day. In some cases, doses may be increasing gradually to 3000 mg daily.
For loss of vision associated with age (age related macular degeneration): a combination product that contains 100 mg of acetyl-L carnitine, 530 mg of omega-3 fatty acids, and 10 mg of Q-10 coenzyme per day for one year (Phototrop, Sigma-tau Health Science, Ltd.)
A combination of 100 mg of coenzyme Q10 (Bio-Quinon, Pharma Nord) twice daily plus 200 mcg of selenium yeast (SelenoPrecise, Pharma Nord) per day for up to 5 years.
For cardiac disease: 100 mg per day divided into two or three doses up to 4 months or 2 mg / kg per day up to one year.
Diabetic neuropathy for nerve damage: 400 mg daily for 12 weeks.
For fibromyalgia: approximately 6 weeks 300 mg daily. Moreover, 200 mg of coenzyme Q10 (Bio-Quinon Q10, Pharma Nord) plus 200 mg ginkgo per day for 12 weeks.
For HIV / AIDS: for more than 4 years 100-200 mg daily.
For complications of the blood vessel caused by the cardiac bypass operation: 150 to 300 mg per day at up to three divided doses 1 to 2 weeks before the operation.
For a certain type of hypertension: 60 mg twice daily for 12 weeks.
To avoid headache migraines: 100 mg three times daily, 150 mg once daily, or 100 mg once daily for three months. A dose of 1-3 mg / kg per day was also used for 3 months.
For a muscle disorder known as muscle dystrophy: 100 mg per day for three months.
For MS: 500 mg twice daily for three months.
In people with recent heart failure, the risk of future cardiac events is reduced: 120 mg daily at two divided doses for up to one year. Also used for up to one year were 100 mg of Q10 coenzyme (Bio-Quinon, Pharma Nord) and 100 mcg of selenium (Bio-Selenium, Pharma Nord) daily.
For the disease of Peyronie: 300 mg daily for six months.
- For deficiency of coenzyme Q10: 60-250 mg per day at up to three separate doses.
- For the prevention of migraine headaches: 1-3 mg / kg daily is used for three months in patients 3-18 years of age.
- For a muscular disorder known as muscular dystrophy, 100 mg daily for three months in children aged between 8 and 15 years.